JC-171 IN 3 Smiles: NCCOCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

Smiles: NCCOCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

InChi: InChI=1S/C43H74N14O11/c1-22(2)20-31-40(65)52-26(10-15-44)35(60)51-29(13-18-47)39(64)57-34(24(4)59)43(68)49-19-14-30(53-36(61)28(12-17-46)54-42(67)33(48)23(3)58)38(63)50-27(11-16-45)37(62)56-32(41(66)55-31)21-25-8-6-5-7-9-25/h5-9

1-12H3/b15-14-

These results indicate that inhibition of BMP signaling may successfully target both the tumor and the surrounding microenvironment to reduce tumor burden and metastasis

JC-171 IN 3 Smiles: NCCOCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=OJC 171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8. 45 M for inhibiting LPS ATP induced interleukin 1 (IL 1) release from J774A. 1 macrophages. Product information CAS Number: 2112809 98 8 Molecular Weight: 384. 83 Formula: C16H17ClN2O5S Chemical Name: 5 chloro N {2 [4 (hydroxysulfamoyl)phenyl]ethyl} 2 methoxybenzamide Smiles: COC1=CC=C(Cl)C=C1C(=O)NCCC1C=CC(=CC=1)S(=O)(=O)NO InChiKey: KQRQPMUPYDOTCA UHFFFAOYSA N InChi: InChI=1S